Fig. 6: Programmable ADP-ribosylation of thymine generates distinct editing outcomes in bacteria and eukaryotes compared to deaminase and glycosylase base editing. | Nature Biotechnology

Fig. 6: Programmable ADP-ribosylation of thymine generates distinct editing outcomes in bacteria and eukaryotes compared to deaminase and glycosylase base editing.

From: Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes

Fig. 6: Programmable ADP-ribosylation of thymine generates distinct editing outcomes in bacteria and eukaryotes compared to deaminase and glycosylase base editing.The alternative text for this image may have been generated using AI.

Editors with deaminases include ABEs60 and CBEs61, while editors with glycosylases include A-to-Y BEs41, glycosylase BEs62, adenine transversion BEs63, glycosylase-based guanine BEs64, glycosylase-based TBEs, glycosylase-based CBEs35, DAF-TBEs, DAF-CBEs33, thymine DNA glycosylase-based editor, cytosine DNA glycosylase-based editor42 and TBEs34. Nucleotides representing edits are colored to help compare the glycosylation and ADP-ribosylation of thymine.

Back to article page