Extended Data Fig. 2: Analysis of ligand-receptor interactions in a model of human lung adenocarcinoma tumors infused with meso-CAR-T cells.
From: A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors
a, Chord diagrams showing an overview of intercellular communication and the number of identified interactions in the meso-tumor (left) and control (middle) groups. Each chord represents a bundle of paired and statistically significant ligand-receptor interactions between a particular pair of cell types (right). The width of the chord indicates the number of interacting ligand-receptor pairs. A random-permutation test was used in the CellPhoneDB method to calculate empirical p values. b-e, Chord diagrams of cell pair-specific ligand-receptor interactions with p-values < 0.05 and total mean expression > 0.35. A random-permutation test was used in the CellPhoneDB method to calculate empirical p values.
