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In vivo CAR-Ts captivate big pharma

In-body manufacturing promises a faster, cheaper and simpler alternative to CAR-T cell therapy — if the field can deliver clinical readouts that prove long-term safety and efficacy.

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A.M. consults for Haystack Science; no company mentioned in this story is a client.

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Marshall, A. In vivo CAR-Ts captivate big pharma. Nat Biotechnol 43, 1893–1896 (2025). https://doi.org/10.1038/s41587-025-02955-8

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