Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Career Feature
  • Published:

Career feature

Sustainability of gap funding programs aimed at commercializing academic innovation

Rutgers University’s approach to building an effective and sustainable technology commercialization fund emphasizes getting industry input early to improve outcomes in the short and long term.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: General funding spectrum from discovery to market.
Fig. 2: The overall process overview of Rutgers University’s gap funding programs.

References

  1. DiMasi, J. A., Grabowski, H. G. & Hansen, R. W. J. Health Econ. 47, 20–33 (2016).

    Article  PubMed  Google Scholar 

  2. DiMasi, J. A. JAMA Intern. Med. 178, 587 (2018).

    Article  PubMed  Google Scholar 

  3. Gowder, C. Useful stats: NIH SBIR/STTR application success rates & trends, FY 2012-2021. https://ssti.org/blog/useful-stats-nih-sbirsttr-application-success-rates-trends-fy-2012-2021 (22 July 2022).

  4. Litan, R. E., Mitchell, L. & Reedy, E. J. The university as innovator: bumps in the road. Issues in Science and Technology https://issues.org/litan/ (2007).

  5. Antman, E. M. et al. Nat. Rev. Drug Discov. 16, 663–664 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Johnson, J. Mind the Gap Report (Innovosource, 2022).

  7. Zwick, M. E. J. Biomol. Tech. 32, 36–41 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Thomas, C. J. & McKew, J. C. Curr. Top. Med. Chem. 14, 291–293 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gunjan, S. Nat. Biotechnol. 30, 474 (2012).

  10. Deerfield Management. Washington University and Deerfield Management launch VeritaScience to drive drug discovery. https://www.prnewswire.com/news-releases/washington-university-and-deerfield-management-launch-veritascience-to-drive-drug-discovery-302035698.html (16 January 2024).

  11. Reece, E. A. et al. Health Aff. (Millwood) 44, 140–147 (2025).

    Article  PubMed  Google Scholar 

  12. United for Medical Research. NIH’s Role in Sustaining the US Economy. https://www.unitedformedicalresearch.org/wp-content/uploads/2024/03/UMR-NIHs-Role-in-Sustaining-the-US-Economy-2024-Update.pdf (2025).

  13. US National Science Foundation. Biotechnology https://www.nsf.gov/focus-areas/biotechnology (2025).

  14. NIH NCATS. More treatments for all people more quickly https://ncats.nih.gov/research/overview (2025).

  15. NIH SEED. Product Development Support https://seed.nih.gov/product-development-support (2025).

  16. Anderson, B. J., Leonchuk, O., O’Connor, A. C., Shaw, B. K. & Walsh, A. C. J. Clin. Transl. Sci. 6, e7 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  17. Global Biodefense. NIH REACH program to speed commercialization of health technologies. https://globalbiodefense.com/2015/03/24/nih-reach-program-to-speed-commercialization-of-health-technologies/ (24 March 2015).

  18. Balch, B. How uncertainty around cuts to scientific research is impacting the future biomedical research workforce. AAMC https://www.aamc.org/news/how-uncertainty-around-cuts-scientific-research-impacting-future-biomedical-research-workforce (16 April 2025).

  19. Malcom, K. $20M Frankel innovation initiative set to kick off third round of funding. Michigan Medicine https://www.michiganmedicine.org/news-release/20m-frankel-innovation-initiative-set-kick-third-round-funding (28 March 2022).

  20. NJ Economic Development Authority. NJEDA Financing and Incentives/New Jersey Innovation Evergreen Fund https://www.njeda.gov/financing-and-incentives/ (2025)

  21. Colorado Office of Economic Development and International Trade. Advanced Industries Proof of Concept Grant https://oedit.colorado.gov/advanced-industries-proof-of-concept-grant (2025).

  22. Michigan State University Innovation Center. Advance Grant Proof-of-Concept Fund https://innovationcenter.msu.edu/tech-transfer-commercialization/programs-and-resources/advance-grant-proof-of-concept-fund/ (accessed 15 May 2025).

  23. Rutgers University launches TechAdvance funding program to advance inventions toward commercialization. New Jersey Business Magazine (19 June 2017).

  24. Celgene donates $100K to Rutgers’ TechAdvance gap funding program. Innovosource https://www.innovosource.com/celgene-donates-100k-to-rutgers-techadvance-gap-funding-program/ (16 August 2018).

  25. Rutgers Office for Research. Rutgers Office for Research announces new patent policy. https://research.rutgers.edu/news/rutgers-office-research-announces-new-patent-policy (19 July 2022).

  26. Rutgers University Patent Policy https://policies.rutgers.edu/B.aspx?BookId=12014&PageId=459338 (accessed 15 December 2025).

  27. US National Science Foundation. Technology, Innovation and Partnerships: a directorate at the U.S. National Science Foundation. https://www.nsf.gov/tip/latest (2025).

Download references

Acknowledgements

The Rutgers HealthAdvance program is partially supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under award number U01HL150852. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pragati Sharma.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sharma, P., Smeraglia, V.A., Zwick, M.E. et al. Sustainability of gap funding programs aimed at commercializing academic innovation. Nat Biotechnol 44, 155–159 (2026). https://doi.org/10.1038/s41587-025-02972-7

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41587-025-02972-7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing