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RNA vaccines

Tuning the immune response to mRNA vaccines

Nature Biotechnology (2026) Cite this article

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A strategy to control translation of mRNA vaccines reveals cell type–specific contributions to immunity that may be harnessed to enhance vaccine efficacy.

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Fig. 1: microRNA platform for cell-specific mRNA silencing and limitations in translating to humans.
The alternative text for this image may have been generated using AI.

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Authors and Affiliations

  1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA

    Haseeb Mughal

  2. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

    Haseeb Mughal, Yizong Hu & Daniel G. Anderson

  3. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    Yizong Hu & Daniel G. Anderson

  4. Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children’s Hospital, Boston, MA, USA

    Daniel G. Anderson

  5. Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA

    Daniel G. Anderson

  6. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA

    Daniel G. Anderson

Authors
  1. Haseeb Mughal
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  2. Yizong Hu
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  3. Daniel G. Anderson
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Corresponding author

Correspondence to Daniel G. Anderson.

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Competing interests

H.M. and Y.H. declare no competing interests. D.G.A discloses competing interest due to past and present advising roles for Alnylam, Sanofi, Translate Bio, oRNA Therapeutics, CRISPR Therapeutics, Souffle Therapeutics and Combined Therapeutics.

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Mughal, H., Hu, Y. & Anderson, D.G. Tuning the immune response to mRNA vaccines. Nat Biotechnol (2026). https://doi.org/10.1038/s41587-026-03125-0

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