Supplementary Figure 3
From: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
Protein structure for Alr Alanine racemase mutational map showing the position and effect of mutations based on measure of protein stability by DUET. Unfavourable mutations are depicted in blue and favourable mutations are depicted in red, where color intensity reflects the extent of effect. The PLP cofactor is shown as a stick representation in green. a, The protomer structure of alanine racemase depicted as a cartoon with the PLP cofactor shown as sticks. b, The active site with residues that have been identified in the GWAS depicted as sticks and their hydrogen bonding propensity shown as dashed black lines
