Supplementary Figure 5: BCL11A binds to both the proximal and distal TGACC sites in the γ-globin promoter. | Nature Genetics

Supplementary Figure 5: BCL11A binds to both the proximal and distal TGACC sites in the γ-globin promoter.

From: Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

Supplementary Figure 5

a, There are two TGACC motifs within the proximal promoter of the γ-globin gene, located at approximately –115 and –90 bp with respect to the TSS. b, The BCL11A ZF can bind to both the proximal and distal TGACC sites in the γ-globin promoter via EMSA in vitro. These data represent n = 1 independent experiment.

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