Supplementary Figure 6: ZBTB7A ChIP–seq in K562 cells. | Nature Genetics

Supplementary Figure 6: ZBTB7A ChIP–seq in K562 cells.

From: Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

Supplementary Figure 6: ZBTB7A ChIP–seq in K562 cells.The alternative text for this image may have been generated using AI.

a, ZBTB7A binding across the γ-globin genes in four biologically independent replicates (n = 4) of ZBTB7A ChIP–seq in K562 cells. b, Shown are the top five motifs as identified using MEME-ChIP. The analysis was performed on the peaks generated from n = 4 biologically independent replicates. c, TALENs cut at the ATG of both endogenous γ-globin genes. TdTomato is integrated by homologous recombination from a donor vector with 1-kb arms of homology. The donor plasmid contains either the WT or –195C>G γ- promoter.

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