Supplementary Figure 7: ZBTB7A ChIP–seq in HUDEP-2 cells. | Nature Genetics

Supplementary Figure 7: ZBTB7A ChIP–seq in HUDEP-2 cells.

From: Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

Supplementary Figure 7

a, ZBTB7A ChIP–seq tracks across the β-globin locus in HUDEP-2(ΔGγ) WT and –195C>G cells. LCR, locus control region. These data represent n = 1 independent experiment. b, ZBTB7A binding at control promoter regions of GATA1 and KLF1 in HUDEP-2(ΔGγ) cells. These data represent n = 1 independent experiment. c,d, ZBTB7A binding motifs from ChIP–seq in HUDEP-2 cells. Shown are the top five motifs as identified using MEME-ChIP, known similar motifs and their distribution within the peak in HUDEP-2(ΔGγ) WT (c) and –195C>G (d) cells. The analysis was performed on the peaks generated from n = 1 independent experiment.

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