Supplementary Figure 7: Gene Ontology enrichment
From: Highly parallel genome variant engineering with CRISPR–Cas9
Data is shown as dot-plots overlaid with box-and-whisker plots. The centerline of each box corresponds to the data's median value; the top and bottom of the box span from the first quartile to the third quartile of the data; and the whiskers reach to either the data's most extreme values or 1.5 times the interquartile range. See also Supplementary Table 4. a, Gene tolerance scores for genes in the biological process category of “RNA splicing, via spliceosome,” compared to the remaining tested genes (n = 69 and 965, respectively; Kolmogorov-Smirnov test, Bonferroni corrected P = 0.0017) b, Gene tolerance scores for genes in the molecular function category of “catalytic activity,” compared to the remaining tested genes (n = 477 and 557, respectively; Kolmogorov-Smirnov test, Bonferroni corrected P = 0.0024).
