Supplementary Figure 11: Predicted effects of human NMD on PTCs, for human genes that are homologs of essential yeast genes | Nature Genetics

Supplementary Figure 11: Predicted effects of human NMD on PTCs, for human genes that are homologs of essential yeast genes

From: Highly parallel genome variant engineering with CRISPR–Cas9

Supplementary Figure 11: Predicted effects of human NMD on PTCs, for human genes that are homologs of essential yeast genesThe alternative text for this image may have been generated using AI.

For human genes, we plot the fraction of PTCs escaping NMD regulation according to the 50-bp rule (Nagy, E. & Maquat, L. E. A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem. Sci. 23, 198–199; 1998) versus distance from gene ends. Note that the majority of PTCs within the last 27 codons are predicted to escape NMD regulation.

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