Supplementary Figure 3: Distinct 450K methylation probes at the KLF14 locus are associated to rs4731702 vs age. | Nature Genetics

Supplementary Figure 3: Distinct 450K methylation probes at the KLF14 locus are associated to rs4731702 vs age.

From: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

Supplementary Figure 3: Distinct 450K methylation probes at the KLF14 locus are associated to rs4731702 vs age.

Figure shows results for two 450K probes assayed in the TwinsUK adipose samples (N=603). cg02385110, which is ~3KB upstream of KLF14 is shown on the left, cg08097417 which is at the KLF14 transcription start site is shown on the right. The beta distributions (top row), association to rs4731702 (T2D risk allele homozygotes = 2) (middle row) and association to age (bottom row) differ between the two probes. cg02385110 has a higher mean beta value, is associated to rs4731702 (P=2.1x10-7), and is not associated to age (P=0.64). In contrast, cg08097417 is not associated to rs4731702 (P=0.99) but is highly associated to age (P=3.6x10-61). Associations were tested with linear mixed effect models adjusting for batch effects, BMI and famlly structure

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