Supplementary Fig. 14: Pharmacological inhibition of ARP2/3 restores neurite length in CTNNA2-mutant, but not MDS, neurons. | Nature Genetics

Supplementary Fig. 14: Pharmacological inhibition of ARP2/3 restores neurite length in CTNNA2-mutant, but not MDS, neurons.

From: Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration

Supplementary Fig. 14: Pharmacological inhibition of ARP2/3 restores neurite length in CTNNA2-mutant, but not MDS, neurons.

ARP2/3 inhibition by CK-869 rescued the neurite length defect in CTNNA2-mutant dissociated neurons, but not in wild-type and MDS mutant neurons. Quantification shown as a box plot: top box, Q3; bottom box, Q1, median. The whiskers represent the minimum and maximum values observed in the dataset. Repeated in three independent iPSC clones per patient or three CTNNA2KO clones, 581 cells were scored. ***, significant P values (see “Statistics and reproducibility”). Scale bar, 50 μm.

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