Supplementary Figure 10: Copy number alterations affecting interferon signaling by drug class.
From: Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
a, Proportion of samples harboring a CNA disrupting interferon-γ signaling by drug class using a definition of clinical benefit from Roh et al. (2017). For the anti-CTLA-4 condition, n = 145; two-sided Fisher’s exact test P = 0.021. For the anti-PD-1/PD-L1 condition, n = 94; two-sided Fisher’s exact test P = 0.038. b, Proportion of samples harboring a CNA disrupting interferon signaling by drug class using a definition of clinical benefit from Van Allen et al. (2015). For the anti-CTLA-4 condition, n = 133; two-sided Fisher’s exact test P = 0.008. For the anti-PD-1/PD-L1 condition, n = 92; two-sided Fisher’s exact test P = 0.073. Two-sided Fisher’s exact test: *P < 0.05. Error bars represent standard error above and below the group proportion.
