Supplementary Figure 14: Biallelic loss of genes involved in JAK–STAT signaling.
From: Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
a, Samples with biallelic loss (truncating mutation with deletion of the wild-type allele) of at least one gene in the JAK–STAT pathway are shown. Color indicates mutation class. The bottom tile plot indicates clinical response to immune checkpoint therapy. b, Samples with mutations or copy number alterations leading to biallelic loss in antigen-presentation pathway genes are shown. c, Copy number plot demonstrating biallelic loss of β2-microglobulin via a homozygous deletion in a patient with melanoma.
