Supplementary Figure 5: DEPICT enrichment analysis.
DEPICT software was used to investigate enrichment of a range of biological properties. In each case, we compared known sentinel SNPs (n = 357) to all known and novel SNPs with P < 1 x 10−12 (n = 227). The gene set enrichment analysis algorithm is described in Pers et al.66. Enrichment –log P-value is reported for both groups; we also present delta –log P-value as a measure of novelty introduced by novel associations reported. Enrichment categories are as follows. (a) Enrichment of tissues and cell types. (b) GO annotation. (c) Protein-protein interaction subnetwork annotation. (d) Mammalian phenotype annotation.
