Supplementary Figure 4: Enrichment of cross-tissue epigenetic states in T2D GWAS data. | Nature Genetics

Supplementary Figure 4: Enrichment of cross-tissue epigenetic states in T2D GWAS data.

From: Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Supplementary Figure 4: Enrichment of cross-tissue epigenetic states in T2D GWAS data.

fGWAS log2 fold enrichment (based on joint model for each tissue) including 95% confidence intervals (x-axis) of all chromatin states (y-axis) genome-wide. Analyses are based on the Varshney et al.1 data which combined standard epigenomic annotations for the four principal tissues of interest. These analyses performed separately for each tissue show some enrichment for enhancers and/or promoters in all tissues with strongest and most consistent enrichment observed in islets. The universally enriched “transcript” category refers to coding sequence which is by definition represented by the same sequence in each “tissue-specific” analysis. 1Varshney, A. et al. Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proc Natl Acad Sci U S A 114, 2301-2306 (2017).

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