Supplementary Figure 6: Epigenome landscape of the ST6GAL1 locus.

For variants included in 99% credible set (PPA>1%) of each distinct signal at ST6GAL1 locus, following information is shown: genomic position of each variant (colour coded for each distinct signal; variant with highest PPA in bold); whole genome bisulphite methylation data (black), 4 human islet ATAC-seq tracks (green, middle), islet chromatin states (from Thurner et al.¹, Pasquali et al.², and Varshney et al.³); and adipose, liver and skeletal muscle chromatin states from Varshney et al.³. ¹ Thurner, M. et al. Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci. Elife 7(2018). ² Pasquali, L. et al. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Nat Genet 46, 136-143 (2014). ³ Varshney, A. et al. Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proc Natl Acad Sci U S A 114, 2301-2306 (2017).