Supplementary Figure 10: Polygenic risk scores. | Nature Genetics

Supplementary Figure 10: Polygenic risk scores.

From: Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Supplementary Figure 10: Polygenic risk scores.

Genome-wide polygenic risk score (PRS) identifies individuals with significantly increased risk of T2D. a) PRS in UK Biobank individuals is normally distributed with a shift towards right, observed for T2D cases. PRS is plotted on the x-axis, with values scaled to a mean of 0 and standard deviation of 1. b) Individuals were binned into 40 groups based on PRS, with each grouping representing 2.5% of population. c) BMI distribution in T2D cases, within each PRS bin.

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