Supplementary Figure 1: Sex-differentiated analyses.
(a) Manhattan plot (top panel) of genome-wide association results for T2D (without BMI adjustment) from female-specific meta-analysis of up to 30,053 cases and 434,336 controls. The association p-value (on -log10 scale) for each SNP (y-axis) is plotted against the genomic position (NCBI Build 37; x-axis). Association signals that reached genome-wide significance (p < 5×10−8) in sex-combined analysis are shown in purple or yellow, if novel. (b) Manhattan plot (bottom panel) of genome-wide association results for T2D without BMI adjustment from male-specific meta-analysis of up to 41,846 cases and 383,767 controls. (c) Z-score for each of the 403 distinct signals from male-specific analysis (y-axis) is plotted against the z-score from the female-specific analysis (y-axis). Colour of each point varies with –log10 gender heterogeneity p-value and diameter of the circle is proportional to sex-combined -log10 p-value.
