Supplementary Fig. 9: Effect sizes of thermotolerance loci depend on genetic background.

Each panel reports a comparison of the impact on thermotolerance of allelic variation at the indicated gene, in the indicated diploid backgrounds. In a given panel, the gray bar reports the mean growth efficiency at 39 °C of a hybrid strain harboring a wild-type copy of the allele from S. paradoxus Z1 of the focal gene and a full deletion of the allele from S. cerevisiae DBVPG1373, normalized by the analogous quantity measured in a hybrid with a wild-type S. cerevisiae allele and a deletion in the S. paradoxus allele, from the insets of Fig. 2. The orange bar reports the mean growth efficiency at 39 °C of a strain of the S. cerevisiae DBVPG1373 background harboring the allele from S. paradoxus Z1 of the focal gene, normalized by the analogous quantity measured in wild-type S. cerevisiae DBVPG1373, from Fig. 3a. The blue bar reports the mean growth efficiency at 39 °C of wild-type S. paradoxus Z1, normalized by the analogous quantity measured in a strain of S. paradoxus Z1 harboring the allele from S. cerevisiae DBVPG1373 of the focal gene, from Fig. 3b. Individual measurements are reported as circles. Sample numbers for the gray, orange and blue bars are as reported in Fig. 2 insets, Fig. 3a and Fig. 3b, respectively.