Supplementary Fig. 6: Epinephrine treatment rescues body-curvature defects in ciliary mutants. | Nature Genetics

Supplementary Fig. 6: Epinephrine treatment rescues body-curvature defects in ciliary mutants.

From: Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis

Supplementary Fig. 6: Epinephrine treatment rescues body-curvature defects in ciliary mutants.

a–d, Phenotypes of kif3b (a,b) and ovl (c,d) mutants treated with DMSO or epinephrine (epi). e,f, Epinephrine treatment induced dorsal curvature in wild-type embryos. g, Statistical analysis of the angles of body curvature of kif3b (a,b) and ovl (c,d) mutants treated with DMSO or epinephrine. ***P < 0.001, Student’s t-test. h, Relative travel distance of fluorescent beads in wild-type or zmynd10 (z10) mutants after DMSO or epinephrine treatment. NS, not significant with two-way ANOVA test. Scale bar, 500 µm.

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