Supplementary Figure 6: Genes connected to p63 by direct binding, direct cohesin contact, or via one element are negatively regulated. | Nature Genetics

Supplementary Figure 6: Genes connected to p63 by direct binding, direct cohesin contact, or via one element are negatively regulated.

From: Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment

Supplementary Figure 6

a, Histograms of Monte Carlo simulation of the number of genes (blue) in a randomly generated gene list that are connected to p63 in day 7 p63WT cells through 0°, 1°, 2°, or 3° contacts. This is compared to the number of p63-dependent genes connected to p63 in these same configurations at day 7 (red). FDR is <0.05 for all configurations except 3° connections. b, ecdf of the change in expression level (day 7 p63WT versus day 7 p63KO) of genes connected to p63 by 0º (orange), 1º (blue), 2º (green), 3º (purple), and all (red) connections compared to all genes (black). n is the number of genes, two-sided t test.

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