Supplementary Figure 12: SCHLAP1-induced chromatin changes do not cause concordant gene expression changes.
From: SWI/SNF remains localized to chromatin in the presence of SCHLAP1
Significance and changes in expression of gene expression microarrays performed by Prensner et al.1 on RWPE1;LACZ or RWPE1;SCHLAP1 cells compared to the altered chromatin regions. Each panel represents the set of regions that open, close, or remain static in our ATAC-seq assay. b, Quantification of the number of genes that are significantly differentially expressed and that are associated with an ATAC-seq peak. These represent those genes that fall below the adjusted P-value threshold of 0.05 in a. P values are from gene expression changes from GSE40385, reanalyzed using the limma package, with no fold change cutoff and adjusted P < 0.05 to identify significant genes.
