Table 1 Association of mLOY with age, smoking, cancer risk and mortality

From: Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’

 

OR/HR

95% CI

Association P value

Heterogeneity P value

Age at DNA collection

Blood

1.16

(1.14–1.18)

<2.0 × 10−16

3.27 × 10−5

Buccal

1.10

(1.08–1.12)

<2.0 × 10−16

Current smoking

Blood

3.07

(2.15–4.38)

6.1 × 10−10

0.045

Buccal

1.81

(1.25–2.64)

1.9 × 10−3

Cancer risk (All)

Blood

1.26

(1.06–1.50)

0.010

0.358

Buccal

1.48

(1.10–1.99)

0.010

Cancer risk (DNA before Dx)

Blood

1.17

(0.97–1.42)

0.100

0.704

Buccal

1.07

(0.70–1.62)

0.760

Cancer risk (DNA at or after Dx)

Blood

1.43

(1.11–1.85)

0.006

0.442

Buccal

1.69

(1.20–2.37)

0.003

All-cause mortalitya

Blood

0.87

(0.73–1.03)

0.100

0.526

Buccal

0.99

(0.69–1.42)

0.960

Cancer mortalitya

Blood

0.83

(0.68–1.01)

0.060

0.258

Buccal

1.07

(0.72–1.58)

0.750

  1. aIndicates that hazard ratios are reported in place of odds ratios. Age and smoking models are adjusted for smoking/age, contributing study and ancestry. Cancer-risk models are adjusted for age, smoking, contributing study and ancestry. Mortality models are for individuals from prospective cohort studies with case DNA collected ≥1 year before cancer diagnosis and adjusted for age, smoking, cancer diagnosis, contributing study and body mass index. OR, odds ratio; HR, hazard ratio; CI, confidence interval; Dx, cancer diagnosis.
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