Supplementary Fig. 5: Enrichment levels (log OR) and extent of sharing between traits for 25-state chromatin segmentations of the NIH Roadmap and ENCODE projects at the T < 10–8 GWAS significance threshold. | Nature Genetics

Supplementary Fig. 5: Enrichment levels (log OR) and extent of sharing between traits for 25-state chromatin segmentations of the NIH Roadmap and ENCODE projects at the T < 10–8 GWAS significance threshold.

From: GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

Supplementary Fig. 5

a, Distribution of significant OR values across the 29 traits considered, split by segmentation state and colored to highlight predicted functional elements by Roadmap Epigenomics (see Supplementary Table 9). Number of points n is shown on the x axis below each category. b, Distribution of the pairwise difference between ORs from all enhancer, promoter and transcriptional enhancers and transcriptional regulatory states tested (‘state 1’) to ORs from transcription states for significant enrichments only (‘state 2’; for example, measuring ORc,tEnhA1 − ORc,tTx for all cell types c and traits t for which P-valuec,tEnhA1 and P-valuec,tTx are both significant). Number of points n is shown on the x axis below each category. c, Sharing of significantly enriched/depleted annotations across 27 phenotypes (excluding CD and UC). The bar plot displays the number of cell types where an annotation is uniquely enriched in a trait or shared among multiple traits.

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