Supplementary Figure 5: Transcriptome alterations and genetic subclades. | Nature Genetics

Supplementary Figure 5: Transcriptome alterations and genetic subclades.

From: Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis

Supplementary Figure 5

(a) Schematic depicts number of differentially expressed (DE) genes obtained by comparing transcriptome data for strains in the three major genetic subclades at mid-exponential (ME) and early-stationary (ES) phases. (b) Fold-increase in nga-ifs-slo transcript levels in SC2A (n = 15) strains compared to SC1A (n = 12) and SC1B (n = 23) strains at ME and ES phase. (c) grab gene transcript levels (normalized counts) were significantly increased in SC1B (n = 23) strains compared to SC1A (n = 12) strains at both growth phases (ME and ES). A significant increase in grab transcript levels in SC2A (n = 15) strains compared to SC1A (n = 12) strains was observed at ES phase. Statistical tests were performed using Mann-Whitney (two-tailed) test. Data are presented as box and whisker plots, where whiskers represent the minimum and maximum values. n represents the number of strains; each strain has three independent biological replicates.

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