Supplementary Figure 11: Patients with osteosarcoma presenting complex Y chromosome rearrangements coupled to interchromosomal translocations. | Nature Genetics

Supplementary Figure 11: Patients with osteosarcoma presenting complex Y chromosome rearrangements coupled to interchromosomal translocations.

From: Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

Supplementary Figure 11: Patients with osteosarcoma presenting complex Y chromosome rearrangements coupled to interchromosomal translocations.

a–c) X-axes are clipped at 30 Mb to exclude the Yq heterochromatic region. Vertical grey lines represent inter-chromosomal rearrangements with a) chromosome 11, b) chromosomes 1, 19, and 22, and c) chromosome 15. d) Distribution of each Y-Y junction orientation (n = number of breakpoint junctions). e) Distribution of microhomology or insertion lengths with each dot representing an individually reconstructed Y-Y breakpoint junction. f) Distribution of intra-DSB distances pooled across all three examples.

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