Supplementary Figure 4: Non-uniform phenotype of CIN in CRC.
From: Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
(a) Genome-wide copy number plots of two tumor PDOs that were independently H2B-Neon infected expressing tumor PDOs (9 and 9_2). Each row represents a cell and the copy-number state (2Mb bins) is indicated in colors. (b) Quantification of segregation errors observed in independently infected H2B-Neon expressing tumor PDOs. Alternative representation of data shown in Figure 2C. n = 2 or 3 independent experiments. Centre values are the mean. (c) Correspondence of our nomenclature to the one used in (Roerink, S. F. et al. Nature 556, 457–462, 2018) (d) Expression of mismatch repairs genes (MLH1, PMS2, MSH2 and MSH6) analyzed by immunohistochemistry. n = 1 independent experiment.
