Supplementary Figure 2: Karyotype of healthy colon tissue and colon PDOs.
From: Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
(a) Chromosome numbers distribution of cells of healthy colon PDOs and tumor PDOs, as determined by metaphase spreads. n = 1, 2 or 3 independent experiments. Centre values are the median. (b) Bulk genome-wide copy number plots of two healthy colon PDOs show euploidy. n = 1 independent experiment. (c) Genome-wide single cell copy number plots (scKaryo-seq) of one healthy colon tissue. Each row represents a cell and the copy-number state (5Mb bins) is indicated in colors. (d) Genome-wide copy number profile of six single cells of one healthy colon tissue. Example of single cells described in (C). The copy-number state (5Mb bins) is indicated in colors.
