Supplementary Fig. 9: Transcription changes in K-562 and A549 cells.
From: MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation
a, Heat map of relative transcription changes in K-562 cells treated with with 0.1 μM dBET6, 1 μM (S)-JQ1, 1 μM MTX, shRNAs targeting BRD4 or MTHFD1 alone or in combination. Equal amount of DMSO, or non-targeting hairpins were used as respective controls. b, Heat map matrix of relative transcription changes in A549 treated with 0.1 μM dBET6, 1 μM (S)-JQ1, 1 μM MTX, shRNAs targeting BRD4 or MTHFD1 alone or in combination. Equal amount of DMSO, or non-targeting hairpins were used as respective controls.
