Supplementary Figure 2: Comparison of allelic imbalances in SuRE, H3K27ac and ATAC-seq.
From: High-throughput identification of human SNPs affecting regulatory element activity
a. Comparison of allelic imbalance of SuRE signals and H3K27ac ChIP-seq signals (normalized for genomic DNA allelic read counts) for raQTLs for which K562 cells are heterozygous and at least 10 H3K27ac reads covered the raQTL. REF: reference allele; ALT: alternative allele; OR: odds-ratio. b. Same as (a.) but for ATAC-seq. c-e. Average profile of DNase-seq (c), ATAC-seq (d) and H3K27ac (e) signal for all raQTLs that are heterozygous in K562 cells. The vertical gray lines indicate the raQTL position and the horizontal gray lines indicate the approximate background signal. Note how the signal relative to background is much better for DNase-seq than for these ATAC-seq or H3K27ac signals.
