Supplementary Figure 3: Illustration of data and links for prioritization, evidence, druggability and effect output in rheumatoid arthritis (RA).

a, The front page with a navigation tab listing main features and an interface “Pi Reveal” searching for traits and targets. b, The trait-specific page for prioritized target genes. c, A tabular display of the top 5 genes in target pathway crosstalk together with an overview of evidence, druggability and effect. d, Illustration of data and links for one prioritized gene, CD40, showing evidence used in Pi for this gene and thus accelerating decision-making on target selection. This includes but is not limited to: (i) target priority info, linked to details on genomic predictors (for example, cell types/states in which eQTLs and eGenes are identified together with magnitude and directionality of effect), annotation predictors and interaction/network plot; and (ii) target druggable info, where available, including DGIdb druggable gene categories and PDB druggable pockets (linked to details and 3D View of the PDB protein structure embedded with druggable pockets shown in blue).