Supplementary Figure 1: pcHi-C in human pancreatic islets. | Nature Genetics

Supplementary Figure 1: pcHi-C in human pancreatic islets.

From: Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

Supplementary Figure 1: pcHi-C in human pancreatic islets.The alternative text for this image may have been generated using AI.

Supplementary Fig. 1. a, Schematic representation of the pcHi-C analysis workflow. b, Relative frequency of high-confidence interactions between baits and interacting regions. c, Distances from bait to interacting regions for high-confidence interactions. The dashed line represents the median distance. d, CHiCAGO score distribution of high-confidence interactions in merged pcHi-C data (n=175,784) and individual islet samples, and in distance-matched interactions. Boxplots show IQR, and whiskers show 5th and 95th percentiles. e, Pairwise Pearson correlation values of CHiCAGO scores between individual islet samples and merged dataset. f-g. Epigenomic maps and virtual 4C profiles in merged and individual human islet samples in TCF7L2 and ISL1. h,i. pcHi-C recapitulates interactions identified by 4C-seq in human islets and the human β cell line EndoC-βH1 at ISL1 and MAFB loci. The top track depicts a virtual 4C representation of human islet pcHi-C data in both promoters. High-confidence interactions from 4 pooled human islet samples and naïve CD4+ T cells are shown below. Inverted triangles depict viewpoints.

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