Supplementary Figure 5: HERV-H elements are enriched at ESC(+) TAD boundaries. | Nature Genetics

Supplementary Figure 5: HERV-H elements are enriched at ESC(+) TAD boundaries.

From: Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells

Supplementary Figure 5

(a) Aggregated RNA-seq expression profile (RPKM normalized) at ESC(+) TAD boundaries that overlap each of the eight repeat elements (HERVH-int and LTR7 are combined as they both belong to HERV-H). (b) Heatmap of DI scores within 70 kb of the top 50 most highly-expressed HERV-Hs. (c,d,e) heatmaps displaying Hi-C contacts for three ESC(+) TAD boundaries harboring HERV-H/LTR7 sequences are shown together with the DI, CTCF ChIP-seq, histone modification H3K27ac and RNA-seq profiles at the corresponding regions.

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