Extended Data Fig. 9: Ratio of the heterozygote rate in EAS to that in EUR for existing and new loci.
From: Comparative genetic architectures of schizophrenia in East Asian and European populations
Het(EAS) and Het(EUR), calculated as 2f(1−f), are the heterozygote rates for a variant in EAS and EUR respectively, in which f is the variant allele frequency in EAS or EUR. Power to identify genetic associations increases with the expected non-centrality parameter for the association, which is proportional to the heterozygote rate. Therefore, we use the ratio of the heterozygote rate in EAS to that in EUR as a measure of the relative power to identify genetic association of the same effect size in the two populations. A ratio greater than 1 means that EAS samples have more power to identify the association and vice versa. Existing loci are those that are genome-wide significant in the previous study of European ancestry2, and new loci are those that are genome-wide significant just in this study combining EAS and EUR samples. Sample sizes utilized were EAS stage 1 (n = 13,305 cases; 16,244 controls) and EUR samples (n = 33,640 cases; 43,456 controls).
