Extended Data Fig. 8: The contribution of anti-cancer treatments to the mutation burden of tumors (according to SignatureAnalyzer).

a, Comparison of the contribution of different treatments and the aging signature to the mutation burden of tumors originated in different organs. b, c Contribution in total number (upper) and proportion (lower) of all treatment-associated SBS b, and DBS c, to the mutation burden of metastatic tumors originated in different organs. d, First column: distribution of the contribution of treatments (and the aging signature) to the mutation burden of tumors exposed to them. Second column: distribution of the contribution of treatments (and the aging signature) to the mutation burden of tumors during one month of exposure.