Extended Data Fig. 4: Mapping of bulk transcriptomes onto developmental populations.
From: Stalled developmental programs at the root of pediatric brain tumors
Best matching signatures using ssGSEA for all samples within each tumor type. For ATRT tumors, populations from a recently published timecourse of the developing mouse cerebellum38 spanning E10-P14 were also included in the projections; cerebellar signatures are denoted by ‘CB’. HGNET-BCOR, high-grade neuroepithelial tumor with BCOR alteration; EBT, embryonal brain tumor; HGG-IDH, IDH-mutant high-grade gliomas; HGG-WT, High-grade gliomas wild-type for histone and IDH1/2 mutations; HF, signature from published scRNA-seq human fetal brain dataset24 containing human cerebral cortex specimens spanning 5-37 PCW. Bars are colored by cluster from which signatures were derived.
