Extended Data Fig. 5: The sub-nuclear localisation of enhancer-MYC regions.
a) Comparison of the sub-nuclear distribution of MYC and its OSE in relation to the nuclear periphery in HCECs using the “c” value strategy. The data is based on two independent experiments counting in total 300 alleles (p value: two-sided Fisher’s exact test). b) ChrISP analysis showing the proximity between the OSE and MYC. Each dot represents a ChrISP signal indicating proximity between one allele of the OSE and MYC in relation to the position of the OSE to the nuclear periphery/pore (a total of 310 alleles were counted in two independent experiments) (p value: two-sided Fisher’s exact test). c) ChrISP analyses of proximities between EnhD and MYC in relation to the position of the EnhD to the nuclear periphery. The number of counted alleles (155) was derived from three independent experiments (p value: two-sided Fisher’s exact test).
