Extended Data Fig. 7: METTL3 depletion leads to accumulation of RNA:DNA hybrids in hPSCs. | Nature Genetics

Extended Data Fig. 7: METTL3 depletion leads to accumulation of RNA:DNA hybrids in hPSCs.

From: N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

Extended Data Fig. 7: METTL3 depletion leads to accumulation of RNA:DNA hybrids in hPSCs.

METTL3 depletion leads to accumulation of RNA:DNA hybrids in hPSCs. (a) The results of S9.6 DRIP qPCR of the indicated repeats and intronic sequences performed on siCTL and siMETTL3 hiPSCs sorted at different cell cycle phases. (b) Relative expression of the indicated transcripts in siCTL and siMETTL3 hiPSCs. The difference between the values of Y-axes in (a) and in Fig. 3b is due to incorporation of RNase H control samples in the analysis shown in Fig. 3b. Data are means ± SD, n = 3 independent experiments.

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