Extended Data Fig. 8: Detection of Selection in subsets of mutations.
From: Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
SNVs and indels from all cases (n=18) were aggregated into 4 different subsets: clonal = variants found in the MRCA (n=378453); subclonal = variants not found in the MRCA (n=516136); pre-diaspora = variants found above the diaspora founder clone in the phylogenetic tree (n=313545); post-diaspora = variants found in the diaspora founder or in clones below the founder in the phylogenetic tree (n=295316). Within each subset, dN/dS analysis was performed separately on: missense variants; truncating variants. Bars show maximum likelihood estimates of dN/dS values, with values greater than 1 (dashed line) indicating positive selection. Vertical lines = 95% confidence intervals, estimated using Wald test.
