Extended Data Fig. 6: Pathway and GATA6 expression analysis of our cohort.
From: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution
a, Enriched pathways identified by GSEA of Basal-like-A/B versus Classical-A/B tumours. b, Frequency of genetically intact SMAD4 allele (left panel), TP53 mutation (middle panel) and complete loss of CDKN2A (right panel) in the subtypes. P-values are from two-sided Fisher’s exact test (n = 225 cohort; individual n values shown in the plot). c, GATA6 amplifications (normalized for ploidy) from Fig. 3d separated based on primary (n = 170) and metastatic (n = 58) tumours. p-values are from the Kruskal-Wallis test. d, GATA6 expression in primary and metastatic tumours according to subtypes. Same tumours as above. p-values are from the Kruskal-Wallis test. Box whisker plots shown median and first/third quartiles with all points. Primary (n = 170); mets (n = 58). e, Correlation of GATA6 expression and copy number. To account for ploidy related changes, the copy number of GATA6 was normalized to the ploidy. Two-sided Spearman correlation coefficient, p-values and the number of tumours in each subtype are shown on the plot. f, Representative (of n = 3 patients) RNAish images for GATA6 expression of adjacent exocrine tissue (duct/acinar cells) from a patient where normal parenchyma was present.
