Extended Data Fig. 10: Analysis of two patients which demonstrated a change in tumour subtype with disease progression. | Nature Genetics

Extended Data Fig. 10: Analysis of two patients which demonstrated a change in tumour subtype with disease progression.

From: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

Extended Data Fig. 10: Analysis of two patients which demonstrated a change in tumour subtype with disease progression.The alternative text for this image may have been generated using AI.

a, Positions of Compass_0003 and Compass_0064 tumours on the consensus clustering dendrogram of the molecular subtypes. b, RNAish for GATA6 on liver biopsy from Compass_0003. Lack of GATA6 expression confirms Basal-like phenotype. c, Genomic analysis of Compass_0003 and Compass_0064. Bar plots show numbers of SNVs and indels. Circos plots show genome-wide SVs. d, Copy number and germline SNP plots for chr12 from diagnosis (top panel) and liver metastasis (bottom panel). A unique duplication event that amplified mutant KRAS is found only in metastasis. e, Integrative genomics viewer (IGV) image of genomic region showing the paired-end reads (green) that denote the duplication event from (d) in liver metastasis of Compass_0003 (bottom panel). The same duplication is absent at diagnosis (top panel) but is present in the primary tumour-derived xenograft (PDX; middle panel). f, Celluloid plot of the PDX generated from the primary tumour of Compass_0003. g, Copy number and germline SNP plots of chromosome 12 showing KRAS status at diagnosis (top panel) and progression (bottom panel) of Compass_0064.

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