Extended Data Table 2 Association between variant allele fraction (VAF) of CH mutations and clinical characteristics

From: Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Variable (reference)

 

OR

95% CI

p

Age

–

1

1–1.1

0.0011

Ethnicity (white)

Asian

1

0.94–1.2

0.42

Black

0.9

0.82–1

0.053

Other

0.93

0.83–1

0.24

Unknown

0.92

0.8–1.1

0.22

Smoking status (non-smoker)

Smoker

1.1

1.1–1.2

0.000023

Therapy (untreated)

Treated

1

0.96–1.1

0.8

PD status (Non-PD non-myeloid)

Myeloid PD

1.3

1.3–1.4

<1 × 10−6

Non-myeloid PD

1.3

1.2–1.5

0.000052

Non-PD myeloid

0.99

0.92–1.1

0.8

Number of mutations (1)

≥ 2

1.1

1.1–1.2

0.0000038

  1. Generalized estimating equations were used to test for association between VAF of CH mutations (among those with a mutation) and selected clinical and mutational features, accounting for correlation between the VAF of mutations in the same person. Age expressed in decile.
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