Extended Data Fig. 5: Determinants and consequences of cellular heterogeneity.
From: Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
a, Association between RHP variability scores and somatic non-silent mutations. We compared the variability of each program in mutated and non-mutated cell lines using two-sided t-test. Model cell lines (high variability) of EMT-II, IFN response and p53-dependent senescence RHPs are depleted of NOTCH4, MRE11 and TP53 mutations, respectively. Horizontal lines indicate the median. b, Association between drug response (CTRP database) and program variability calculated using linear regression including tumor type and program variability as independent variables. Increased sensitivity to NOTCH inhibition (gamma secretase inhibitors) and MDM2 inhibition (Nutlin-3) were observed in model cell lines (high variability) of the EMT-II and the p53-dependent senescence respectively.
