Extended Data Fig 6: Similarities and differences between senescence-related expression programs.
From: Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
a, Significance (-log10(P), hypergeometric test) of the overlaps between sets of genes upregulated upon senescence, as defined by multiple studies (see Table S8). b, Most common genes across the different senescence programs, including all genes appearing in at least three programs, ranked from top to bottom by the number of programs. c, Density of RHP signature genes within sliding windows of 300 genes, among the top 6,000 expressed genes, arranged by their expression response to etoposide, from the most upregulated (top) to the most downregulated (bottom), as also shown in Fig. 6b. RHPs are sorted from left to right by their enrichment with upregulated and downregulated genes, respectively. d, e, Significance of gene-set overlaps (d), and the most common genes (e), as in (a, b), when restricting the analysis to secreted genes, in order to define SASP.
