Extended Data Fig. 10: Association between the abundance of EpiSen cells and clinical response of HNSCC patients to Cetuximab.
From: Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
a, Volcano plots depict differential expression analysis comparing bulk pretreatment samples of HSNCC patients with short (n = 14) and long (n = 26) PFS following Cetuximab treatment plus platinum-based chemotherapy. Comparisons were performed using two-sided t-test, and P values were adjusted using the FDR procedure. Genes in the HNSCC EpiSen program from cell lines (in vitro, top panel) and tumors (in vivo, middle panel) are highlighted, as well as those shared between the two programs (bottom panel). b, Heatmap showing the expression of shared EpiSen genes in samples stratified into short and long PFS. Genes are order by differential expression (log2(fold change)), as shown in (a), and tumors are ordered within each group according to the EpiSen score. Top panels depicts sample type, tumor stage (T), tumor grade, and site of primary tumors.
