Extended Data Fig. 1: ACE2 expression patterns in the mouse and human lung cells infected with the respiratory syncytial virus (RSV) and nasal washes from ferrets infected with SARS-CoV-2. | Nature Genetics

Extended Data Fig. 1: ACE2 expression patterns in the mouse and human lung cells infected with the respiratory syncytial virus (RSV) and nasal washes from ferrets infected with SARS-CoV-2.

From: Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor

Extended Data Fig. 1

a, Sashimi plots of the Ace2 region in a lung RNA-seq dataset from mice mock/RSV- infected in triplicates. The expression of dAce2-Ex1c is not observed and Ace2 expression is not affected by the infection. b, Sashimi plots of the ACE2 region in H292, a human lung mucoepidermoid pulmonary carcinoma cell line. Expression of ACE2 from Ex1a and Ex1b is very low, while the dACE2 from Ex1c is expressed at baseline and is further induced by RSV infection. c, Representative IGV plots showing exon and exon-exon junction RNA-seq reads from nasal washes of mock/SARS-CoV-2-infected ferrets. The expression of dAce2-Ex1c is not observed. Note: The mouse and human/ferret ACE2/Ace2 genes are shown in opposite orientations, as presented in IGV. The positions corresponding to the human dACE2-Ex1c are marked in the mouse and ferret genomes. Datasets: PRJNA588982, PRJNA61503.

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