Extended Data Fig. 4: Assessing the individual impact of step 4 of PolyFun (re-estimating per-SNP heritabilities within each bin excluding the target chromosome) via perturbation analysis, by not excluding the target chromosome from the re-estimation procedure. | Nature Genetics

Extended Data Fig. 4: Assessing the individual impact of step 4 of PolyFun (re-estimating per-SNP heritabilities within each bin excluding the target chromosome) via perturbation analysis, by not excluding the target chromosome from the re-estimation procedure.

From: Functionally informed fine-mapping and polygenic localization of complex trait heritability

Extended Data Fig. 4: Assessing the individual impact of step 4 of PolyFun (re-estimating per-SNP heritabilities within each bin excluding the target chromosome) via perturbation analysis, by not excluding the target chromosome from the re-estimation procedure.

The figure is similar to Extended Data Figure 1 but applies a different perturbation (disables the exclusion of the target chromosome, either when using the default sample size N = 320 K or when using a smaller sample size of N = 10 K). Numerical reports are provided in Supplementary Table 6.

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