Extended Data Fig. 4: Discriminative ability and highest GRS decile odds ratio of the African ancestry genome-wide GRS upon iteratively adding each variant to the GRS model. | Nature Genetics

Extended Data Fig. 4: Discriminative ability and highest GRS decile odds ratio of the African ancestry genome-wide GRS upon iteratively adding each variant to the GRS model.

From: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Extended Data Fig. 4: Discriminative ability and highest GRS decile odds ratio of the African ancestry genome-wide GRS upon iteratively adding each variant to the GRS model.

a) European ancestry men from the UK Biobank and b) African ancestry men from the California Uganda (CA UG) study. Variants are sorted first within the 269-variant genetic risk score (GRS) then for other genome-wide variants by the African ancestry genome-wide association study (GWAS) meta-analysis P-values (with four P-value thresholds indicated by dotted vertical lines), and GRS weights are based on African ancestry GWAS meta-analysis results. Black lines represent the area under the curve (AUC) and correspond to the left y-axis, while blue lines represent the 90-100% GRS odds ratio (OR; relative to 40-60% GRS) and correspond to the right y-axis. All statistical tests were two-sided. PCs: principal components.

Back to article page